Assay Detail
Binding
CHEMBL4015809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human D4R expressed in CHO cell membranes by radioligand binding assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased D2R Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.84 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100183 | — | — | 1 | 8.32 |
| CHEMBL4072780 | — | — | 1 | 8.08 |
| CHEMBL4092441 | — | — | 1 | 7.51 |
| CHEMBL4061986 | — | — | 1 | 7.26 |
| CHEMBL4064742 | — | — | 1 | 7.22 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.20 |
| CHEMBL4083239 | — | — | 1 | 7.18 |
| CHEMBL2165126 | — | — | 1 | 7.12 |
| CHEMBL4102628 | — | — | 1 | 7.12 |
| CHEMBL4064186 | — | — | 1 | 7.03 |
| CHEMBL4083727 | — | — | 1 | 6.80 |
| CHEMBL4091507 | — | — | 1 | 6.72 |
| CHEMBL4073330 | — | — | 1 | 6.57 |
| CHEMBL4091933 | — | — | 1 | 6.52 |
| CHEMBL4099666 | — | — | 1 | 6.06 |
| CHEMBL4068702 | — | — | 1 | 5.68 |
| CHEMBL4070604 | — | — | 1 | 5.50 |
| CHEMBL4084690 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100183 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4072780 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL4092441 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL4061986 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL4064742 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL4083239 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2165126 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL4102628 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4064186 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL4083727 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4091507 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL4073330 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4091933 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4099666 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL4068702 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL4070604 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL4084690 | — | Ki | = | 5000.0 | nM | 5.30 |