Assay Detail
Binding
CHEMBL4015837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by immunoprecipitation assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.40 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064619 | — | — | 1 | 8.29 |
| CHEMBL3700093 | — | — | 1 | 7.89 |
| CHEMBL3700084 | — | — | 1 | 7.85 |
| CHEMBL4081831 | — | — | 1 | 7.77 |
| CHEMBL3700072 | — | — | 1 | 7.77 |
| CHEMBL3700071 | — | — | 1 | 7.62 |
| CHEMBL4090609 | — | — | 1 | 7.50 |
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.46 |
| CHEMBL3700098 | — | — | 1 | 7.43 |
| CHEMBL4062646 | — | — | 1 | 7.17 |
| CHEMBL3700068 | — | — | 1 | 7.16 |
| CHEMBL4092217 | — | — | 1 | 7.14 |
| CHEMBL3700052 | — | — | 1 | 6.92 |
| CHEMBL3700059 | — | — | 1 | 6.89 |
| CHEMBL3700061 | — | — | 1 | 6.82 |
| CHEMBL3700085 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064619 | — | EC50 | = | 5.1 | nM | 8.29 |
| CHEMBL3700093 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3700084 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4081831 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3700072 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3700071 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4090609 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2431768 | LCL-161 | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3700098 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4062646 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3700068 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4092217 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3700052 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3700059 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3700061 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3700085 | — | EC50 | = | 180.0 | nM | 6.75 |