Assay Detail
Binding
CHEMBL4016019
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full length N-terminal His-tagged dCTPase expressed in Escherichia coli BL21(DE3) using dCTP as substrate by HTS-based malachite green assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.62 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072033 | — | — | 1 | 7.72 |
| CHEMBL4082508 | — | — | 1 | 7.60 |
| CHEMBL4060634 | — | — | 1 | 7.47 |
| CHEMBL4075978 | — | — | 1 | 7.44 |
| CHEMBL4101470 | — | — | 1 | 7.42 |
| CHEMBL4091797 | — | — | 1 | 7.39 |
| CHEMBL4098065 | — | — | 1 | 7.29 |
| CHEMBL4061657 | — | — | 1 | 7.19 |
| CHEMBL4065129 | — | — | 1 | 6.77 |
| CHEMBL2315104 | — | — | 1 | 6.62 |
| CHEMBL4086571 | — | — | 1 | 6.60 |
| CHEMBL4092758 | — | — | 1 | 6.59 |
| CHEMBL4080038 | — | — | 1 | 6.58 |
| CHEMBL4069309 | — | — | 1 | 6.46 |
| CHEMBL4090348 | — | — | 1 | 6.30 |
| CHEMBL4084024 | — | — | 1 | 6.28 |
| CHEMBL4070933 | — | — | 1 | 5.96 |
| CHEMBL4062310 | — | — | 1 | 5.77 |
| CHEMBL591796 | — | — | 1 | 5.55 |
| CHEMBL4073664 | — | — | 1 | 5.50 |
| CHEMBL463763 | TRIPTOLIDE | 3.0 | 1 | 4.51 |
| CHEMBL4100482 | — | — | 1 | - |
| CHEMBL4065076 | — | — | 1 | - |
| CHEMBL2315103 | — | — | 1 | - |
| CHEMBL4102948 | — | — | 1 | - |
| CHEMBL4085001 | — | — | 1 | - |
| CHEMBL4078027 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072033 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4082508 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4060634 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4075978 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4101470 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4091797 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4098065 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4061657 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4065129 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2315104 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4086571 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4092758 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL4080038 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4069309 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4090348 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL4084024 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4070933 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4062310 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL591796 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4073664 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL463763 | TRIPTOLIDE | IC50 | = | 30900.0 | nM | 4.51 |
| CHEMBL4100482 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4065076 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2315103 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4102948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4085001 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4078027 | — | IC50 | > | 10000.0 | nM | - |