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Assay Detail

CHEMBL4016071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to 5'-FAM labeled TATAGCTATA duplex DNA hairpin (unknown origin) by MST assay
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Not specified
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM.
J Med Chem (2017) 60 : 5407 -5423
PubMed 28514170 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 22 4.75 5.47
Activity 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4073829 1 5.47
CHEMBL222253 1 5.42
CHEMBL4092087 1 5.00
CHEMBL4060318 1 4.99
CHEMBL4087642 1 4.98
CHEMBL4079766 1 4.96
CHEMBL4094411 1 4.90
CHEMBL4100561 1 4.90
CHEMBL4097792 1 4.88
CHEMBL4082226 1 4.63
CHEMBL4102293 1 4.61
CHEMBL4085076 1 4.56
CHEMBL4069001 1 4.53
CHEMBL4076169 1 4.52
CHEMBL4088770 1 4.51
CHEMBL4090081 1 4.47
CHEMBL4105525 1 4.45
CHEMBL4084330 1 4.29
CHEMBL4064369 1 4.26
CHEMBL4103950 1 -
CHEMBL4086031 1 -
CHEMBL4101508 1 -
CHEMBL4074826 1 -
CHEMBL4082541 1 -
CHEMBL4066212 1 -
CHEMBL4093789 1 -
CHEMBL4069956 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4073829 Kd = 3400.0 nM 5.47
CHEMBL222253 Kd = 3790.0 nM 5.42
CHEMBL4092087 Kd = 10100.0 nM 5.00
CHEMBL4060318 Kd = 10200.0 nM 4.99
CHEMBL4087642 Kd = 10500.0 nM 4.98
CHEMBL4079766 Kd = 11000.0 nM 4.96
CHEMBL4094411 Kd = 12600.0 nM 4.90
CHEMBL4100561 Kd = 12500.0 nM 4.90
CHEMBL4097792 Kd = 13200.0 nM 4.88
CHEMBL4082226 Kd = 23300.0 nM 4.63
CHEMBL4102293 Kd = 24700.0 nM 4.61
CHEMBL4085076 Kd = 27300.0 nM 4.56
CHEMBL4069001 Kd = 29500.0 nM 4.53
CHEMBL4076169 Kd = 30000.0 nM 4.52
CHEMBL4088770 Kd = 31200.0 nM 4.51
CHEMBL4090081 Kd = 33700.0 nM 4.47
CHEMBL4105525 Kd = 35200.0 nM 4.45
CHEMBL4084330 Kd = 50700.0 nM 4.29
CHEMBL4064369 Kd = 54700.0 nM 4.26
CHEMBL4103950 Activity - -
CHEMBL4086031 Activity - -
CHEMBL4101508 Kd = 264000.0 nM -
CHEMBL4074826 Kd = 398000.0 nM -
CHEMBL4082541 Activity - -
CHEMBL4066212 Activity - -
CHEMBL4093789 Activity - -
CHEMBL4069956 Kd = 113000.0 nM -