Assay Detail
Functional
CHEMBL4016087
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Antiproliferative activity against human CA46 cells after 48 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CA46 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.59 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222253 | — | — | 1 | 8.00 |
| CHEMBL4069001 | — | — | 1 | 7.70 |
| CHEMBL4087642 | — | — | 1 | 7.30 |
| CHEMBL4082226 | — | — | 1 | 6.77 |
| CHEMBL4097792 | — | — | 1 | 6.42 |
| CHEMBL4102293 | — | — | 1 | 6.27 |
| CHEMBL4084330 | — | — | 1 | 5.97 |
| CHEMBL4079766 | — | — | 1 | 5.89 |
| CHEMBL4060318 | — | — | 1 | 5.82 |
| CHEMBL4092087 | — | — | 1 | 5.64 |
| CHEMBL4088770 | — | — | 1 | 5.56 |
| CHEMBL4105525 | — | — | 1 | 5.52 |
| CHEMBL4069956 | — | — | 1 | 5.25 |
| CHEMBL4085076 | — | — | 1 | 5.21 |
| CHEMBL4094411 | — | — | 1 | 5.12 |
| CHEMBL4082541 | — | — | 1 | 5.01 |
| CHEMBL4101508 | — | — | 1 | 4.97 |
| CHEMBL4073829 | — | — | 1 | 4.94 |
| CHEMBL4090081 | — | — | 1 | 4.89 |
| CHEMBL4093789 | — | — | 1 | 4.86 |
| CHEMBL4103950 | — | — | 1 | 4.85 |
| CHEMBL4063446 | — | — | 1 | 4.85 |
| CHEMBL4086031 | — | — | 1 | 4.83 |
| CHEMBL4066212 | — | — | 1 | 4.82 |
| CHEMBL4064369 | — | — | 1 | 4.66 |
| CHEMBL4100561 | — | — | 1 | 4.34 |
| CHEMBL4074826 | — | — | 1 | - |
| CHEMBL4076169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222253 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4069001 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4087642 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4082226 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4097792 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4102293 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4084330 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4079766 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4060318 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4092087 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL4088770 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL4105525 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL4069956 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4085076 | — | IC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL4094411 | — | IC50 | = | 7550.0 | nM | 5.12 |
| CHEMBL4082541 | — | IC50 | = | 9730.0 | nM | 5.01 |
| CHEMBL4101508 | — | IC50 | = | 10640.0 | nM | 4.97 |
| CHEMBL4073829 | — | IC50 | = | 11530.0 | nM | 4.94 |
| CHEMBL4090081 | — | IC50 | = | 12760.0 | nM | 4.89 |
| CHEMBL4093789 | — | IC50 | = | 13850.0 | nM | 4.86 |
| CHEMBL4103950 | — | IC50 | = | 14020.0 | nM | 4.85 |
| CHEMBL4063446 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4086031 | — | IC50 | = | 14750.0 | nM | 4.83 |
| CHEMBL4066212 | — | IC50 | = | 15120.0 | nM | 4.82 |
| CHEMBL4064369 | — | IC50 | = | 22020.0 | nM | 4.66 |
| CHEMBL4100561 | — | IC50 | = | 46090.0 | nM | 4.34 |
| CHEMBL4074826 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4076169 | — | IC50 | > | 50000.0 | nM | - |