Assay Detail
Binding
CHEMBL4016337
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Inhibition of cynomolgus monkey 11beta-HSD1
5
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.00 | 8.42 |
| Ki | 1 | 8.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080667 | — | — | 3 | 8.42 |
| CHEMBL4073762 | — | — | 2 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080667 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4073762 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4080667 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4080667 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4073762 | — | IC50 | = | 24.8 | nM | 7.61 |