Assay Detail

CHEMBL4016797

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Inhibition of phenylephrine-induced contractions in dog femoral vein after 15 to 20 mins post phenylephrine-induced contraction

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Canis lupus familiaris
Tissue	Femoral vein
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.

Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, Fey P, Griebenow N, Kroh W, Becker-Pelster EM, Kretschmer A, Geiss V, Li V, Straub A, Mittendorf J, Jautelat R, Schirok H, Schlemmer KH, Lustig K, Gerisch M, Knorr A, Tinel H, Mondritzki T, Trübel H, Sandner P, Stasch JP.
J Med Chem (2017) 60 : 5146 -5161
PubMed 28557445 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.51	5.51

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4066936	VERICIGUAT	4.0	1	5.51

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4066936	VERICIGUAT	IC50	=	3072.0	nM	5.51