Assay Detail

CHEMBL4016825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Stimulation of rat sGC expressed in CHO cells using GTP as substrate assessed as increase in cGMP formation treated for 6 mins in presence of sGC inhibitor ODQ by luminescence assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Loading context

Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.

Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, Fey P, Griebenow N, Kroh W, Becker-Pelster EM, Kretschmer A, Geiss V, Li V, Straub A, Mittendorf J, Jautelat R, Schirok H, Schlemmer KH, Lustig K, Gerisch M, Knorr A, Tinel H, Mondritzki T, Trübel H, Sandner P, Stasch JP.
J Med Chem (2017) 60 : 5146 -5161
PubMed 28557445 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.59	6.59

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4066936	VERICIGUAT	4.0	1	6.59

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4066936	VERICIGUAT	EC50	=	256.0	nM	6.59