Assay Detail
Binding
CHEMBL4016880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CLK1/4 in human MDA-MB-231 cells assessed as down regulation of EGFR expression after 3 days by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1/CLK4 (CHEMBL4106176) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.38 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082113 | — | — | 1 | 5.38 |
| CHEMBL4094143 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082113 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4094143 | — | IC50 | > | 20000.0 | nM | - |