Assay Detail
Binding
CHEMBL4017023
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Inhibition of HDAC1/2/3/6 in human Cal27 cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.64 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069631 | — | — | 1 | 6.57 |
| CHEMBL4090647 | — | — | 1 | 6.43 |
| CHEMBL4080343 | — | — | 1 | 6.43 |
| CHEMBL4095934 | — | — | 1 | 6.15 |
| CHEMBL4095157 | — | — | 1 | 6.12 |
| CHEMBL4059953 | — | — | 1 | 6.06 |
| CHEMBL4098365 | — | — | 1 | 6.02 |
| CHEMBL4066076 | — | — | 1 | 5.87 |
| CHEMBL4074686 | — | — | 1 | 5.85 |
| CHEMBL4088198 | — | — | 1 | 5.75 |
| CHEMBL4100732 | — | — | 1 | 5.69 |
| CHEMBL4082736 | — | — | 1 | 5.53 |
| CHEMBL4068613 | — | — | 1 | 5.16 |
| CHEMBL4090555 | — | — | 1 | 4.84 |
| CHEMBL4082838 | — | — | 1 | 4.74 |
| CHEMBL4060958 | — | — | 1 | 4.58 |
| CHEMBL4062588 | — | — | 1 | 4.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069631 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4090647 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4080343 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4095934 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4095157 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4059953 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4098365 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4066076 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4074686 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4088198 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4100732 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL4082736 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4068613 | — | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL4090555 | — | IC50 | = | 14300.0 | nM | 4.84 |
| CHEMBL4082838 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL4060958 | — | IC50 | = | 26200.0 | nM | 4.58 |
| CHEMBL4062588 | — | IC50 | = | 92500.0 | nM | 4.03 |