Assay Detail
Binding
CHEMBL4017028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected Sf9 insect cells using Z-(Ac)Lys-AMC as substrate measured after 90 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.81 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080343 | — | — | 1 | 6.97 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.97 |
| CHEMBL4090647 | — | — | 1 | 6.87 |
| CHEMBL4095934 | — | — | 1 | 6.67 |
| CHEMBL4069631 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080343 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4090647 | — | IC50 | = | 135.0 | nM | 6.87 |
| CHEMBL4095934 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL4069631 | — | IC50 | = | 281.0 | nM | 6.55 |