Assay Detail
Binding
CHEMBL4017045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC1/2/3/6 in human Cal27CisR cells using Boc-Lys(epsilon-Ac)-AMC as substrate preincubated for 18 hrs followed by substrate addition measured after 3 hrs by fluorescence assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.72 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069631 | — | — | 1 | 6.46 |
| CHEMBL4090647 | — | — | 1 | 6.39 |
| CHEMBL4080343 | — | — | 1 | 6.31 |
| CHEMBL4095157 | — | — | 1 | 6.22 |
| CHEMBL4095934 | — | — | 1 | 6.19 |
| CHEMBL4098365 | — | — | 1 | 6.10 |
| CHEMBL4059953 | — | — | 1 | 6.10 |
| CHEMBL4066076 | — | — | 1 | 5.97 |
| CHEMBL4074686 | — | — | 1 | 5.82 |
| CHEMBL4088198 | — | — | 1 | 5.71 |
| CHEMBL4100732 | — | — | 1 | 5.58 |
| CHEMBL4082736 | — | — | 1 | 5.49 |
| CHEMBL4068613 | — | — | 1 | 5.34 |
| CHEMBL4090555 | — | — | 1 | 4.99 |
| CHEMBL4082838 | — | — | 1 | 4.54 |
| CHEMBL4060958 | — | — | 1 | 4.37 |
| CHEMBL4062588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069631 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4090647 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4080343 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4095157 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4095934 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4098365 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4059953 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4066076 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4074686 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4088198 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL4100732 | — | IC50 | = | 2650.0 | nM | 5.58 |
| CHEMBL4082736 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4068613 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL4090555 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4082838 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4060958 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4062588 | — | IC50 | = | 132000.0 | nM | - |