Assay Detail
Functional
CHEMBL4017315
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Antiviral activity against HCV genotype 1b harboring wild type NS5B infected in human HuH7 cells assessed as inhibition of viral RNA replication after 5 days by RT-PCR method
32
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.44 | 7.70 |
| EC90 | 16 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081718 | — | — | 2 | 7.70 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 2 | 7.05 |
| CHEMBL4065765 | — | — | 2 | 7.00 |
| CHEMBL4093378 | — | — | 2 | 6.52 |
| CHEMBL4095814 | — | — | 2 | 6.52 |
| CHEMBL4074383 | — | — | 2 | 6.22 |
| CHEMBL438605 | — | — | 2 | 5.77 |
| CHEMBL4077782 | — | — | 2 | 4.72 |
| CHEMBL4099733 | — | — | 2 | - |
| CHEMBL4101127 | — | — | 2 | - |
| CHEMBL4085639 | — | — | 2 | - |
| CHEMBL4103568 | — | — | 2 | - |
| CHEMBL4082161 | — | — | 2 | - |
| CHEMBL4100162 | — | — | 2 | - |
| CHEMBL4069879 | — | — | 2 | - |
| CHEMBL4090878 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081718 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4065765 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4093378 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4095814 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4074383 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL438605 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4077782 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4101127 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4101127 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4065765 | — | EC90 | = | 0.3 | uM | - |
| CHEMBL4093378 | — | EC90 | = | 0.9 | uM | - |
| CHEMBL4081718 | — | EC90 | = | 0.07 | uM | - |
| CHEMBL4099733 | — | EC90 | > | 100.0 | uM | - |
| CHEMBL4090878 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4069879 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4100162 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4082161 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4103568 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4085639 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4099733 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL438605 | — | EC90 | = | 6.5 | uM | - |
| CHEMBL4090878 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4069879 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4100162 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4082161 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4103568 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4085639 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4095814 | — | EC90 | = | 0.8 | uM | - |
| CHEMBL4077782 | — | EC90 | = | 33.0 | uM | - |
| CHEMBL1259059 | SOFOSBUVIR | EC90 | = | 0.3 | uM | - |
| CHEMBL4074383 | — | EC90 | = | 2.1 | uM | - |