Assay Detail
Functional
CHEMBL4017320
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Antiviral activity against HCV genotype 1a infected in human HuH7 cells assessed as inhibition of viral RNA replication after 96 hrs by RT-PCR method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.06 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.22 |
| CHEMBL4081718 | — | — | 1 | 6.89 |
| CHEMBL4099733 | — | — | 1 | - |
| CHEMBL510394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4081718 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4099733 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL510394 | — | IC50 | > | 100000.0 | nM | - |