Assay Detail
Functional
CHEMBL4017325
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV genotype 4 infected in human HuH7 cells assessed as inhibition of viral RNA replication after 96 hrs by RT-PCR method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.97 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 1 | 7.16 |
| CHEMBL4081718 | — | — | 1 | 6.77 |
| CHEMBL4099733 | — | — | 1 | - |
| CHEMBL510394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1259059 | SOFOSBUVIR | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4081718 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4099733 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL510394 | — | IC50 | > | 100000.0 | nM | - |