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Assay Detail

CHEMBL4017327

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV genotype 1b NS5B S96T mutant
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 1b
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, Tao S, Domaoal RA, Sari O, Schutter C, Amiralaei S, Khalil A, Ollinger Russell O, McBrayer T, Whitaker T, Abou-Taleb N, Amblard F, Coats SJ, Schinazi RF.
J Med Chem (2017) 60 : 5424 -5437
PubMed 28595015 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.89 4.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4088430 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4088430 IC50 = 13000.0 nM 4.89