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Assay Detail

CHEMBL4017328

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of wild type HCV genotype 2a NS5B
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus subtype 2a
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.
Zhou S, Mahmoud S, Liu P, Zhou L, Ehteshami M, Bassit L, Tao S, Domaoal RA, Sari O, Schutter C, Amiralaei S, Khalil A, Ollinger Russell O, McBrayer T, Whitaker T, Abou-Taleb N, Amblard F, Coats SJ, Schinazi RF.
J Med Chem (2017) 60 : 5424 -5437
PubMed 28595015 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.21 5.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4088430 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4088430 IC50 = 6100.0 nM 5.21