Assay Detail
Binding
CHEMBL4017397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length recombinant human MMP13 expressed in mouse NSO cells using varying levels of fTHP-15 as substrate preincubated for 30 mins followed by substrate addition measured immediately by Lineweaver-Burk plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.14 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4061792 | — | — | 1 | 8.80 |
| CHEMBL4080520 | — | — | 1 | 8.77 |
| CHEMBL4089861 | — | — | 1 | 8.74 |
| CHEMBL4062836 | — | — | 1 | 8.64 |
| CHEMBL4100008 | — | — | 1 | 8.04 |
| CHEMBL4081997 | — | — | 1 | 7.87 |
| CHEMBL1371684 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4061792 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4080520 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4089861 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL4062836 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4100008 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL4081997 | — | Ki | = | 13.5 | nM | 7.87 |
| CHEMBL1371684 | — | Ki | = | 800.0 | nM | 6.10 |