Assay Detail
Functional
CHEMBL4017639
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.12 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062965 | — | — | 1 | 7.35 |
| CHEMBL4090898 | — | — | 1 | 6.57 |
| CHEMBL4064044 | — | — | 1 | 6.46 |
| CHEMBL127717 | — | — | 1 | 6.24 |
| CHEMBL49442 | AMETANTRONE | 2.0 | 1 | 6.05 |
| CHEMBL4093358 | — | — | 1 | 5.55 |
| CHEMBL4094285 | — | — | 1 | 5.52 |
| CHEMBL4066762 | — | — | 1 | 5.22 |
| CHEMBL4082118 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062965 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4090898 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4064044 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL127717 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL49442 | AMETANTRONE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4093358 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL4094285 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL4066762 | — | IC50 | = | 5960.0 | nM | 5.22 |
| CHEMBL4082118 | — | IC50 | > | 100000.0 | nM | - |