Assay Detail
Binding
CHEMBL4017666
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Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.20 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100248 | — | — | 1 | 9.03 |
| CHEMBL4092500 | — | — | 1 | 9.03 |
| CHEMBL4071714 | — | — | 1 | 9.01 |
| CHEMBL1569032 | — | — | 1 | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL4101198 | — | — | 1 | 7.76 |
| CHEMBL4074460 | — | — | 1 | 7.60 |
| CHEMBL1334282 | — | — | 1 | 7.48 |
| CHEMBL4097801 | — | — | 1 | 7.24 |
| CHEMBL4090086 | — | — | 1 | 7.22 |
| CHEMBL4088593 | — | — | 1 | 7.01 |
| CHEMBL4066371 | — | — | 1 | 6.79 |
| CHEMBL4060262 | — | — | 1 | 6.77 |
| CHEMBL4096209 | — | — | 1 | 6.71 |
| CHEMBL4088487 | — | — | 1 | 6.67 |
| CHEMBL4060361 | — | — | 1 | 6.59 |
| CHEMBL94551 | — | — | 1 | 6.58 |
| CHEMBL4098655 | — | — | 1 | 6.56 |
| CHEMBL4069119 | — | — | 1 | 6.47 |
| CHEMBL4082231 | — | — | 1 | 6.44 |
| CHEMBL4080725 | — | — | 1 | 6.39 |
| CHEMBL4080618 | — | — | 1 | 6.38 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100248 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL4092500 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL4071714 | — | Ki | = | 0.97 | nM | 9.01 |
| CHEMBL1569032 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4101198 | — | Ki | = | 17.2 | nM | 7.76 |
| CHEMBL4074460 | — | Ki | = | 24.9 | nM | 7.60 |
| CHEMBL1334282 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL4097801 | — | Ki | = | 58.2 | nM | 7.24 |
| CHEMBL4090086 | — | Ki | = | 60.6 | nM | 7.22 |
| CHEMBL4088593 | — | Ki | = | 97.4 | nM | 7.01 |
| CHEMBL4066371 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL4060262 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4096209 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL4088487 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL4060361 | — | Ki | = | 258.0 | nM | 6.59 |
| CHEMBL94551 | — | Ki | = | 263.0 | nM | 6.58 |
| CHEMBL4098655 | — | Ki | = | 276.0 | nM | 6.56 |
| CHEMBL4069119 | — | Ki | = | 335.0 | nM | 6.47 |
| CHEMBL4082231 | — | Ki | = | 362.0 | nM | 6.44 |
| CHEMBL4080725 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL4080618 | — | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 960.0 | nM | 6.02 |