Assay Detail
Binding
CHEMBL4017667
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Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.72 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4090086 | — | — | 1 | 8.43 |
| CHEMBL4066371 | — | — | 1 | 8.29 |
| CHEMBL4100248 | — | — | 1 | 8.21 |
| CHEMBL4080618 | — | — | 1 | 8.20 |
| CHEMBL4082231 | — | — | 1 | 8.20 |
| CHEMBL4098655 | — | — | 1 | 8.14 |
| CHEMBL4060262 | — | — | 1 | 8.13 |
| CHEMBL4088487 | — | — | 1 | 8.12 |
| CHEMBL1334282 | — | — | 1 | 8.11 |
| CHEMBL4092500 | — | — | 1 | 8.09 |
| CHEMBL4071714 | — | — | 1 | 8.08 |
| CHEMBL1569032 | — | — | 1 | 8.08 |
| CHEMBL4096209 | — | — | 1 | 8.06 |
| CHEMBL4097801 | — | — | 1 | 8.05 |
| CHEMBL4069119 | — | — | 1 | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 7.35 |
| CHEMBL4074460 | — | — | 1 | 6.94 |
| CHEMBL4088593 | — | — | 1 | 6.81 |
| CHEMBL94551 | — | — | 1 | 6.79 |
| CHEMBL4060361 | — | — | 1 | 6.75 |
| CHEMBL4101198 | — | — | 1 | 6.66 |
| CHEMBL4080725 | — | — | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4090086 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4066371 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4100248 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4080618 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4082231 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4098655 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL4060262 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4088487 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL1334282 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4092500 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4071714 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL1569032 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL4096209 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL4097801 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4069119 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.2 | nM | 7.60 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL4074460 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL4088593 | — | Ki | = | 154.0 | nM | 6.81 |
| CHEMBL94551 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL4060361 | — | Ki | = | 178.0 | nM | 6.75 |
| CHEMBL4101198 | — | Ki | = | 219.0 | nM | 6.66 |
| CHEMBL4080725 | — | Ki | = | 349.0 | nM | 6.46 |