Assay Detail
Binding
CHEMBL4017668
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Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.86 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.25 |
| CHEMBL4092500 | — | — | 1 | 8.21 |
| CHEMBL4088487 | — | — | 1 | 8.21 |
| CHEMBL4069119 | — | — | 1 | 8.19 |
| CHEMBL4097801 | — | — | 1 | 8.17 |
| CHEMBL4090086 | — | — | 1 | 8.15 |
| CHEMBL1334282 | — | — | 1 | 8.14 |
| CHEMBL4080618 | — | — | 1 | 8.13 |
| CHEMBL4098655 | — | — | 1 | 8.12 |
| CHEMBL4082231 | — | — | 1 | 8.12 |
| CHEMBL4066371 | — | — | 1 | 8.10 |
| CHEMBL4071714 | — | — | 1 | 8.09 |
| CHEMBL4100248 | — | — | 1 | 8.08 |
| CHEMBL1569032 | — | — | 1 | 8.07 |
| CHEMBL4096209 | — | — | 1 | 8.07 |
| CHEMBL4060262 | — | — | 1 | 8.00 |
| CHEMBL4060361 | — | — | 1 | 7.17 |
| CHEMBL4088593 | — | — | 1 | 7.11 |
| CHEMBL4080725 | — | — | 1 | 7.08 |
| CHEMBL94551 | — | — | 1 | 7.04 |
| CHEMBL4074460 | — | — | 1 | 7.02 |
| CHEMBL4101198 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615281 | SLC-0111 | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL4092500 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4088487 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4069119 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL4097801 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL4090086 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL1334282 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL4080618 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4098655 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL4082231 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL4066371 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL4071714 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL4100248 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL1569032 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4096209 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4060262 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL4060361 | — | Ki | = | 66.9 | nM | 7.17 |
| CHEMBL4088593 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL4080725 | — | Ki | = | 83.6 | nM | 7.08 |
| CHEMBL94551 | — | Ki | = | 90.2 | nM | 7.04 |
| CHEMBL4074460 | — | Ki | = | 96.4 | nM | 7.02 |
| CHEMBL4101198 | — | Ki | = | 113.0 | nM | 6.95 |