Assay Detail
Binding
CHEMBL4017746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel small molecule guanidine Sigma1 inhibitors for advanced prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.58 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4098778 | — | — | 1 | 6.96 |
| CHEMBL4084182 | — | — | 1 | 6.67 |
| CHEMBL4092687 | — | — | 1 | 6.38 |
| CHEMBL299499 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4098778 | — | IC50 | = | 109.1 | nM | 6.96 |
| CHEMBL4084182 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL4092687 | — | IC50 | = | 416.8 | nM | 6.38 |
| CHEMBL299499 | — | IC50 | = | 491.4 | nM | 6.31 |