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Assay Detail

CHEMBL4017947

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 measured after 72 hrs by DAPI staining based high throughput screening assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana.
Senadeera SPD, Duffy S, Avery VM, Carroll AR.
Bioorg Med Chem Lett (2017) 27 : 2602 -2607
PubMed 28400231 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.34 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL367149 DOCONEXENT 3.0 1 9.40
CHEMBL361497 ARTESUNATE 4.0 1 9.00
CHEMBL36 PYRIMETHAMINE 4.0 1 8.10
CHEMBL76 CHLOROQUINE 4.0 1 8.03
CHEMBL35228 PYRONARIDINE 3.0 1 7.92
CHEMBL469912 PUROMYCIN 2.0 1 7.21
CHEMBL4098940 1 6.36
CHEMBL4078793 1 5.97
CHEMBL4101406 1 5.75
CHEMBL4059982 1 5.52
CHEMBL3354990 1 5.17
CHEMBL4083418 1 5.05
CHEMBL4093679 1 4.98
CHEMBL4071964 1 4.97
CHEMBL4063338 1 4.95
CHEMBL4072981 1 4.85
CHEMBL4088229 1 4.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL367149 DOCONEXENT IC50 = 0.4 nM 9.40
CHEMBL361497 ARTESUNATE IC50 = 1.0 nM 9.00
CHEMBL36 PYRIMETHAMINE IC50 = 8.0 nM 8.10
CHEMBL76 CHLOROQUINE IC50 = 9.3 nM 8.03
CHEMBL35228 PYRONARIDINE IC50 = 11.9 nM 7.92
CHEMBL469912 PUROMYCIN IC50 = 62.0 nM 7.21
CHEMBL4098940 IC50 = 440.0 nM 6.36
CHEMBL4078793 IC50 = 1070.0 nM 5.97
CHEMBL4101406 IC50 = 1800.0 nM 5.75
CHEMBL4059982 IC50 = 3000.0 nM 5.52
CHEMBL3354990 IC50 = 6700.0 nM 5.17
CHEMBL4083418 IC50 = 8900.0 nM 5.05
CHEMBL4093679 IC50 = 10500.0 nM 4.98
CHEMBL4071964 IC50 = 10700.0 nM 4.97
CHEMBL4063338 IC50 = 11300.0 nM 4.95
CHEMBL4072981 IC50 = 14000.0 nM 4.85
CHEMBL4088229 IC50 = 26900.0 nM 4.57