Assay Detail
Functional
CHEMBL4017948
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 measured after 72 hrs by DAPI staining based high throughput screening assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.32 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL367149 | DOCONEXENT | 3.0 | 1 | 9.37 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.17 |
| CHEMBL35228 | PYRONARIDINE | 3.0 | 1 | 7.75 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 7.21 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.71 |
| CHEMBL4059982 | — | — | 1 | 5.60 |
| CHEMBL4101406 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL367149 | DOCONEXENT | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.67 | nM | 9.17 |
| CHEMBL35228 | PYRONARIDINE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL469912 | PUROMYCIN | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL4059982 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL4101406 | — | IC50 | = | 4000.0 | nM | 5.40 |