Assay Detail
Binding
CHEMBL4018636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant c-Src (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.27 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4105329 | — | — | 1 | 8.41 |
| CHEMBL4062877 | — | — | 1 | 8.24 |
| CHEMBL4075917 | — | — | 1 | 8.22 |
| CHEMBL4067871 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4105329 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4062877 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4075917 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4067871 | — | IC50 | = | 6.4 | nM | 8.19 |