Assay Detail
Binding
CHEMBL4018649
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Inhibition of Erk2 (unknown origin) by FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.13 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4062877 | — | — | 1 | 6.24 |
| CHEMBL4105329 | — | — | 1 | 6.02 |
| CHEMBL4067871 | — | — | 1 | - |
| CHEMBL4075917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4062877 | — | IC50 | = | 574.7 | nM | 6.24 |
| CHEMBL4105329 | — | IC50 | = | 960.2 | nM | 6.02 |
| CHEMBL4067871 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4075917 | — | IC50 | > | 1000.0 | nM | - |