Assay Detail
Functional
CHEMBL4018830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human GLP1 receptor expressed in HEK293 cells harboring mCerulean and mCitrine fused Epac protein assessed as increase in cAMP level up to 30 mins by fluorescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 9.92 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3616711 | — | — | 1 | 10.64 |
| CHEMBL410972 | — | — | 1 | 10.36 |
| CHEMBL4524066 | — | — | 1 | 10.17 |
| CHEMBL4073765 | — | — | 1 | 10.17 |
| CHEMBL4083273 | — | — | 1 | 9.93 |
| CHEMBL4062410 | — | — | 1 | 9.83 |
| CHEMBL4100575 | — | — | 1 | 9.66 |
| CHEMBL4103967 | — | — | 1 | 9.28 |
| CHEMBL4079706 | — | — | 1 | 9.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3616711 | — | EC50 | = | 0.023 | nM | 10.64 |
| CHEMBL410972 | — | EC50 | = | 0.044 | nM | 10.36 |
| CHEMBL4524066 | — | EC50 | = | 0.067 | nM | 10.17 |
| CHEMBL4073765 | — | EC50 | = | 0.068 | nM | 10.17 |
| CHEMBL4083273 | — | EC50 | = | 0.118 | nM | 9.93 |
| CHEMBL4062410 | — | EC50 | = | 0.148 | nM | 9.83 |
| CHEMBL4100575 | — | EC50 | = | 0.221 | nM | 9.66 |
| CHEMBL4103967 | — | EC50 | = | 0.522 | nM | 9.28 |
| CHEMBL4079706 | — | EC50 | = | 0.547 | nM | 9.26 |