Assay Detail

CHEMBL4018845

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ADMET

Binding affinity to human serum albumin

ChEMBL ↗

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Target

Albumin (CHEMBL3253) ↗

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Primary target Albumin

CHEMBL3253

Anchored from Assay target.

Protein identity Albumin

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	ADMET
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Albumin (CHEMBL3253) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues.

Bech EM, Martos-Maldonado MC, Wismann P, Sørensen KK, van Witteloostuijn SB, Thygesen MB, Vrang N, Jelsing J, Pedersen SL, Jensen KJ.
J Med Chem (2017) 60 : 7434 -7446
PubMed 28771355 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	5.84	6.16

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL6	INDOMETHACIN	4.0	1	6.16
CHEMBL898	DIFLUNISAL	4.0	1	5.52

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL6	INDOMETHACIN	Kd	=	700.0	nM	6.16
CHEMBL898	DIFLUNISAL	Kd	=	3000.0	nM	5.52