Assay Detail
Functional
CHEMBL4018859
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Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by CellTiter-Blue assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.27 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908394 | GSK-461364 | 1.0 | 1 | 9.00 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 9.00 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 6.80 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.58 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 6.51 |
| CHEMBL4067978 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908394 | GSK-461364 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL513909 | BI-2536 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL49120 | PD-0166285 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL564829 | MILCICLIB | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4067978 | — | IC50 | = | 1800.0 | nM | 5.75 |