Assay Detail
Binding
CHEMBL4018944
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARgamma LBD by TR-FRET assay
8
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.05 | 10.30 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434063 | — | — | 1 | 10.30 |
| CHEMBL594625 | — | — | 1 | 9.77 |
| CHEMBL603424 | — | — | 1 | 8.74 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 2 | 8.66 |
| CHEMBL413686 | — | — | 2 | 8.47 |
| CHEMBL200732 | — | — | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434063 | — | Ki | = | 0.0497 | nM | 10.30 |
| CHEMBL594625 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL603424 | — | Ki | = | 1.83 | nM | 8.74 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 2.18 | nM | 8.66 |
| CHEMBL413686 | — | Ki | = | 3.42 | nM | 8.47 |
| CHEMBL200732 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL413686 | — | Inhibition | - | % | - | |
| CHEMBL431733 | NAMODENOSON | Inhibition | - | % | - |