Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4018946

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of Fluormone-Pan-PPAR Green from human GST-tagged PPARdelta LBD by TR-FRET assay
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor delta (CHEMBL3979)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Yu J, Ahn S, Kim HJ, Lee M, Ahn S, Kim J, Jin SH, Lee E, Kim G, Cheong JH, Jacobson KA, Jeong LS, Noh M.
J Med Chem (2017) 60 : 7459 -7475
PubMed 28799755 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 9.25 10.99
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL387921 1 10.99
CHEMBL38943 GW501516 2.0 1 10.32
CHEMBL200732 1 9.80
CHEMBL431733 NAMODENOSON 3.0 1 9.37
CHEMBL227279 1 9.21
CHEMBL603424 1 8.62
CHEMBL522152 1 8.60
CHEMBL594625 1 8.58
CHEMBL596014 1 8.53
CHEMBL596042 1 8.50
CHEMBL413686 1 -
CHEMBL119709 IB-MECA 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL387921 Ki = 0.0102 nM 10.99
CHEMBL38943 GW501516 Ki = 0.048 nM 10.32
CHEMBL200732 Ki = 0.16 nM 9.80
CHEMBL431733 NAMODENOSON Ki = 0.43 nM 9.37
CHEMBL227279 Ki = 0.62 nM 9.21
CHEMBL603424 Ki = 2.37 nM 8.62
CHEMBL522152 Ki = 2.54 nM 8.60
CHEMBL594625 Ki = 2.61 nM 8.58
CHEMBL596014 Ki = 2.98 nM 8.53
CHEMBL596042 Ki = 3.15 nM 8.50
CHEMBL413686 Ki = 0.00483 nM -
CHEMBL119709 IB-MECA Inhibition - % -