Assay Detail
Binding
CHEMBL4019028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Serratia marcescens IMP1 expressed in Escherichia coli BL21(DE3) using chromacef as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by HTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Serratia marcescens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metallo-beta-lactamase type 2 (CHEMBL4105964) ↗| Type | SINGLE PROTEIN |
| Organism | Serratia marcescens |
Publication
Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.07 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068259 | — | — | 1 | 6.62 |
| CHEMBL284104 | DIPICOLINIC ACID | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068259 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL284104 | DIPICOLINIC ACID | IC50 | = | 3030.0 | nM | 5.52 |