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Assay Detail

CHEMBL4019422

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Transactivation of human GAL4-fused PPARgamma ligand binding domain expressed in HEL293T cells after 12 to 14 hrs by dual-glo luciferase reporter gene assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Peroxisome proliferator-activated receptor gamma (CHEMBL235)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

A Dual Modulator of Farnesoid X Receptor and Soluble Epoxide Hydrolase To Counter Nonalcoholic Steatohepatitis.
Schmidt J, Rotter M, Weiser T, Wittmann S, Weizel L, Kaiser A, Heering J, Goebel T, Angioni C, Wurglics M, Paulke A, Geisslinger G, Kahnt A, Steinhilber D, Proschak E, Merk D.
J Med Chem (2017) 60 : 7703 -7724
PubMed 28845983 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 4.83 4.83

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4066332 1 4.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4066332 EC50 = 14700.0 nM 4.83