Assay Detail
Binding
CHEMBL4019566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-gp in human HCT116/VM46 cells assessed as reduction in cell viability after 72 hrs by phosphatase assay
184
Total Activities
184
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 184 | 7.34 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4090705 | — | — | 1 | 9.05 |
| CHEMBL4076093 | — | — | 1 | 9.00 |
| CHEMBL4082738 | — | — | 1 | 8.85 |
| CHEMBL4069142 | — | — | 1 | 8.74 |
| CHEMBL4062590 | — | — | 1 | 8.62 |
| CHEMBL4094971 | — | — | 1 | 8.62 |
| CHEMBL4090557 | — | — | 1 | 8.55 |
| CHEMBL4088054 | — | — | 1 | 8.52 |
| CHEMBL4092667 | — | — | 1 | 8.47 |
| CHEMBL4071460 | — | — | 1 | 8.46 |
| CHEMBL4081021 | — | — | 1 | 8.43 |
| CHEMBL4092592 | — | — | 1 | 8.39 |
| CHEMBL4059773 | — | — | 1 | 8.35 |
| CHEMBL4068038 | — | — | 1 | 8.32 |
| CHEMBL4081651 | — | — | 1 | 8.31 |
| CHEMBL4090047 | — | — | 1 | 8.31 |
| CHEMBL4099076 | — | — | 1 | 8.28 |
| CHEMBL4099650 | — | — | 1 | 8.28 |
| CHEMBL4060293 | — | — | 1 | 8.24 |
| CHEMBL4102172 | — | — | 1 | 8.22 |
| CHEMBL4104663 | — | — | 1 | 8.21 |
| CHEMBL4088850 | — | — | 1 | 8.20 |
| CHEMBL4068081 | — | — | 1 | 8.19 |
| CHEMBL4064835 | — | — | 1 | 8.19 |
| CHEMBL4087229 | — | — | 1 | 8.18 |
| CHEMBL4096810 | — | — | 1 | 8.17 |
| CHEMBL4103651 | — | — | 1 | 8.17 |
| CHEMBL4068282 | — | — | 1 | 8.17 |
| CHEMBL4085719 | — | — | 1 | 8.16 |
| CHEMBL4070414 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4090705 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4076093 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4082738 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4069142 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4062590 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4094971 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4090557 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4088054 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4092667 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4071460 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4081021 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4092592 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4059773 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4068038 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4081651 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4090047 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4099076 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL4099650 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL4060293 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4102172 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4104663 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4088850 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4068081 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL4064835 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL4087229 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL4103651 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4068282 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL4096810 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4085719 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4070414 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4105494 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL4073901 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4081777 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4088308 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL4102710 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4074214 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4077516 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4089456 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4078959 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4069314 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL4060924 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4091990 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4059860 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4090205 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4087285 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL4079268 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4103227 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4102508 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4081719 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4099747 | — | IC50 | = | 12.0 | nM | 7.92 |