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Assay Detail

CHEMBL4019568

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Functional
Antiproliferative activity against mouse L1210 cells after 72 hrs by phosphatase assay
ChEMBL ↗
180
Total Activities
180
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1210
Confidence 1 — Organism
Curated By Autocuration

Target

L1210 (CHEMBL386) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
Lukesh JC, Carney DW, Dong H, Cross RM, Shukla V, Duncan KK, Yang S, Brody DM, Brütsch MM, Radakovic A, Boger DL.
J Med Chem (2017) 60 : 7591 -7604
PubMed 28857558 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 180 8.31 10.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4090705 — — 1 10.22
CHEMBL4082738 — — 1 10.22
CHEMBL4062590 — — 1 10.05
CHEMBL4092592 — — 1 9.74
CHEMBL4081777 — — 1 9.60
CHEMBL4096932 — — 1 9.52
CHEMBL4094971 — — 1 9.52
CHEMBL4081651 — — 1 9.52
CHEMBL4104663 — — 1 9.42
CHEMBL4069142 — — 1 9.40
CHEMBL4081021 — — 1 9.40
CHEMBL4077422 — — 1 9.40
CHEMBL4102172 — — 1 9.40
CHEMBL4086760 — — 1 9.40
CHEMBL4068038 — — 1 9.40
CHEMBL4103651 — — 1 9.40
CHEMBL4094539 — — 1 9.30
CHEMBL4089456 — — 1 9.30
CHEMBL4098973 — — 1 9.30
CHEMBL4071460 — — 1 9.30
CHEMBL4088054 — — 1 9.30
CHEMBL4059773 — — 1 9.30
CHEMBL4094367 — — 1 9.22
CHEMBL4059860 — — 1 9.22
CHEMBL4090557 — — 1 9.22
CHEMBL4096810 — — 1 9.22
CHEMBL4094967 — — 1 9.22
CHEMBL4099076 — — 1 9.22
CHEMBL4081996 — — 1 9.22
CHEMBL4074214 — — 1 9.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4082738 — IC50 = 0.06 nM 10.22
CHEMBL4090705 — IC50 = 0.06 nM 10.22
CHEMBL4062590 — IC50 = 0.09 nM 10.05
CHEMBL4092592 — IC50 = 0.18 nM 9.74
CHEMBL4081777 — IC50 = 0.25 nM 9.60
CHEMBL4081651 — IC50 = 0.3 nM 9.52
CHEMBL4094971 — IC50 = 0.3 nM 9.52
CHEMBL4096932 — IC50 = 0.3 nM 9.52
CHEMBL4104663 — IC50 = 0.38 nM 9.42
CHEMBL4069142 — IC50 = 0.4 nM 9.40
CHEMBL4068038 — IC50 = 0.4 nM 9.40
CHEMBL4086760 — IC50 = 0.4 nM 9.40
CHEMBL4102172 — IC50 = 0.4 nM 9.40
CHEMBL4103651 — IC50 = 0.4 nM 9.40
CHEMBL4077422 — IC50 = 0.4 nM 9.40
CHEMBL4081021 — IC50 = 0.4 nM 9.40
CHEMBL4094539 — IC50 = 0.5 nM 9.30
CHEMBL4071460 — IC50 = 0.5 nM 9.30
CHEMBL4098973 — IC50 = 0.5 nM 9.30
CHEMBL4089456 — IC50 = 0.5 nM 9.30
CHEMBL4088054 — IC50 = 0.5 nM 9.30
CHEMBL4059773 — IC50 = 0.5 nM 9.30
CHEMBL4094367 — IC50 = 0.6 nM 9.22
CHEMBL4059860 — IC50 = 0.6 nM 9.22
CHEMBL4090557 — IC50 = 0.6 nM 9.22
CHEMBL4099650 — IC50 = 0.6 nM 9.22
CHEMBL4096810 — IC50 = 0.6 nM 9.22
CHEMBL4094967 — IC50 = 0.6 nM 9.22
CHEMBL4099076 — IC50 = 0.6 nM 9.22
CHEMBL4074214 — IC50 = 0.6 nM 9.22
CHEMBL4096518 — IC50 = 0.6 nM 9.22
CHEMBL4068282 — IC50 = 0.6 nM 9.22
CHEMBL4090047 — IC50 = 0.6 nM 9.22
CHEMBL4081996 — IC50 = 0.6 nM 9.22
CHEMBL4076093 — IC50 = 0.6 nM 9.22
CHEMBL2179942 — IC50 = 0.6 nM 9.22
CHEMBL4090205 — IC50 = 0.6 nM 9.22
CHEMBL4084314 — IC50 = 0.6 nM 9.22
CHEMBL4065379 — IC50 = 0.6 nM 9.22
CHEMBL4102710 — IC50 = 0.6 nM 9.22
CHEMBL4105494 — IC50 = 0.6 nM 9.22
CHEMBL4069314 — IC50 = 0.6 nM 9.22
CHEMBL4092667 — IC50 = 0.65 nM 9.19
CHEMBL4078959 — IC50 = 0.7 nM 9.15
CHEMBL4060293 — IC50 = 0.7 nM 9.15
CHEMBL4087229 — IC50 = 0.7 nM 9.15
CHEMBL4099747 — IC50 = 0.7 nM 9.15
CHEMBL4088850 — IC50 = 0.7 nM 9.15
CHEMBL4073901 — IC50 = 0.7 nM 9.15
CHEMBL4088822 — IC50 = 0.7 nM 9.15