Assay Detail
Functional
CHEMBL4019575
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Antiproliferative activity against human HCT116/VP35 cells after 72 hrs by phosphatase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT116/VP35 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.19 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069142 | — | — | 1 | 8.85 |
| CHEMBL4088308 | — | — | 1 | 8.24 |
| CHEMBL4091990 | — | — | 1 | 8.21 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.20 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069142 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4088308 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL4091990 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 37.0 | nM | 7.43 |