Assay Detail
Functional
CHEMBL4019580
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PA1 cells after 72 hrs by phosphatase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PA-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.62 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069142 | — | — | 1 | 9.00 |
| CHEMBL4088308 | — | — | 1 | 8.64 |
| CHEMBL4091990 | — | — | 1 | 8.59 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.52 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069142 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4088308 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4091990 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.6 | nM | 8.34 |