Assay Detail
Binding
CHEMBL4019652
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Inhibition of CrtN in Staphylococcus aureus USA400 MW2 assessed as reduction in staphyloxanthin levels after 48 hrs by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus subsp. aureus MW2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.11 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4075121 | — | — | 1 | 8.20 |
| CHEMBL3827961 | — | — | 1 | 8.15 |
| CHEMBL4077944 | — | — | 1 | 8.13 |
| CHEMBL4096875 | — | — | 1 | 8.05 |
| CHEMBL4064940 | — | — | 1 | 8.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4075121 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3827961 | — | IC50 | = | 7.08 | nM | 8.15 |
| CHEMBL4077944 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4096875 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4064940 | — | IC50 | = | 9.2 | nM | 8.04 |