Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4019656

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human ERG expressed in CHO cells after 3 mins at -80 mV holding potential by automated patch clamp method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Publication

Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant, and Vancomycin-Intermediate Staphylococcus aureus Infections in Vivo.
Ni S, Wei H, Li B, Chen F, Liu Y, Chen W, Xu Y, Qiu X, Li X, Lu Y, Liu W, Hu L, Lin D, Wang M, Zheng X, Mao F, Zhu J, Lan L, Li J.
J Med Chem (2017) 60 : 8145 -8159
PubMed 28880552 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.48 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4092973 1 6.70
CHEMBL4078841 1 5.89
CHEMBL3828585 1 5.85
CHEMBL4069757 1 5.72
CHEMBL4072535 1 5.72
CHEMBL4096875 1 5.66
CHEMBL4094016 1 5.54
CHEMBL4102707 1 5.54
CHEMBL4103161 1 5.51
CHEMBL4065307 1 5.50
CHEMBL3827961 1 5.50
CHEMBL4090758 1 5.42
CHEMBL4084875 1 5.19
CHEMBL4102178 1 5.17
CHEMBL4075121 1 4.95
CHEMBL4088312 1 4.79
CHEMBL4064940 1 4.49
CHEMBL4077944 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4092973 IC50 = 200.0 nM 6.70
CHEMBL4078841 IC50 = 1300.0 nM 5.89
CHEMBL3828585 IC50 = 1400.0 nM 5.85
CHEMBL4069757 IC50 = 1900.0 nM 5.72
CHEMBL4072535 IC50 = 1900.0 nM 5.72
CHEMBL4096875 IC50 = 2200.0 nM 5.66
CHEMBL4094016 IC50 = 2900.0 nM 5.54
CHEMBL4102707 IC50 = 2900.0 nM 5.54
CHEMBL4103161 IC50 = 3100.0 nM 5.51
CHEMBL4065307 IC50 = 3200.0 nM 5.50
CHEMBL3827961 IC50 = 3200.0 nM 5.50
CHEMBL4090758 IC50 = 3800.0 nM 5.42
CHEMBL4084875 IC50 = 6500.0 nM 5.19
CHEMBL4102178 IC50 = 6700.0 nM 5.17
CHEMBL4075121 IC50 = 11300.0 nM 4.95
CHEMBL4088312 IC50 = 16200.0 nM 4.79
CHEMBL4064940 IC50 = 32100.0 nM 4.49
CHEMBL4077944 IC50 > 40000.0 nM -