Assay Detail
Functional
CHEMBL4019745
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.41 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 5.89 |
| CHEMBL4065412 | — | — | 1 | 5.00 |
| CHEMBL4105561 | — | — | 1 | 4.89 |
| CHEMBL4072816 | — | — | 1 | 4.47 |
| CHEMBL4096345 | — | — | 1 | 4.41 |
| CHEMBL4080695 | — | — | 1 | 4.40 |
| CHEMBL4092104 | — | — | 1 | 4.39 |
| CHEMBL4081642 | — | — | 1 | 4.39 |
| CHEMBL4061419 | — | — | 1 | 4.38 |
| CHEMBL4099640 | — | — | 1 | 4.34 |
| CHEMBL4061360 | — | — | 1 | 4.32 |
| CHEMBL4070033 | — | — | 1 | 4.27 |
| CHEMBL4069085 | — | — | 1 | 4.20 |
| CHEMBL4092530 | — | — | 1 | 4.13 |
| CHEMBL4083264 | — | — | 1 | 4.09 |
| CHEMBL4070085 | — | — | 1 | 4.07 |
| CHEMBL4084779 | — | — | 1 | 4.04 |
| CHEMBL4099703 | — | — | 1 | 4.04 |
| CHEMBL4097225 | — | — | 1 | 4.01 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
| CHEMBL4098798 | — | — | 1 | - |
| CHEMBL4092869 | — | — | 1 | - |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | - |
| CHEMBL4080754 | — | — | 1 | - |
| CHEMBL4064385 | — | — | 1 | - |
| CHEMBL4091055 | — | — | 1 | - |
| CHEMBL4089517 | — | — | 1 | - |
| CHEMBL4081313 | — | — | 1 | - |
| CHEMBL4065864 | — | — | 1 | - |
| CHEMBL4093482 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL566757 | DAPORINAD | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4065412 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4105561 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4072816 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4096345 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL4080695 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4092104 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4081642 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4061419 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL4099640 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL4061360 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4070033 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4069085 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL4092530 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4083264 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL4070085 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL4099703 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL4084779 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL4097225 | — | IC50 | = | 98000.0 | nM | 4.01 |
| CHEMBL4071747 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4063132 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4101228 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4074493 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4093482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4065864 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4081313 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4089517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4091055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4064385 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4080754 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL235191 | TACEDINALINE | IC50 | - | — | - | |
| CHEMBL4092869 | — | IC50 | - | — | - | |
| CHEMBL4098798 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 100000.0 | nM | - |