Assay Detail
Functional
CHEMBL4019819
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of recombinant human mGlu4 receptor expressed in HEK293 cells co-expressing chimeric G protein assessed as increase in EC20 glutamate-induced cAMP level
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.38 | 7.16 |
| Emax | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067875 | — | — | 1 | 7.16 |
| CHEMBL507522 | — | — | 1 | 5.60 |
| CHEMBL4089083 | FOLIGLURAX | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067875 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL507522 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4089083 | FOLIGLURAX | Emax | = | 70.0 | % | - |