Assay Detail
Binding
CHEMBL4019947
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Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.32 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4068667 | — | — | 1 | 8.48 |
| CHEMBL4065471 | — | — | 1 | 8.34 |
| CHEMBL4095983 | — | — | 1 | 8.21 |
| CHEMBL4105199 | — | — | 1 | 7.98 |
| CHEMBL4095042 | — | — | 1 | 7.97 |
| CHEMBL4080951 | — | — | 1 | 7.64 |
| CHEMBL4064911 | — | — | 1 | 7.25 |
| CHEMBL4100348 | — | — | 1 | 7.06 |
| CHEMBL4102803 | — | — | 1 | 6.87 |
| CHEMBL4074577 | — | — | 1 | 6.85 |
| CHEMBL4073512 | — | — | 1 | 6.68 |
| CHEMBL4084848 | — | — | 1 | 6.67 |
| CHEMBL4092607 | — | — | 1 | 6.40 |
| CHEMBL3347643 | — | — | 1 | 6.07 |
| CHEMBL2152332 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4068667 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4065471 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4095983 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL4105199 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4095042 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL4080951 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL4064911 | — | IC50 | = | 55.8 | nM | 7.25 |
| CHEMBL4100348 | — | IC50 | = | 87.9 | nM | 7.06 |
| CHEMBL4102803 | — | IC50 | = | 136.4 | nM | 6.87 |
| CHEMBL4074577 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4073512 | — | IC50 | = | 207.4 | nM | 6.68 |
| CHEMBL4084848 | — | IC50 | = | 214.5 | nM | 6.67 |
| CHEMBL4092607 | — | IC50 | = | 401.0 | nM | 6.40 |
| CHEMBL3347643 | — | IC50 | = | 847.4 | nM | 6.07 |
| CHEMBL2152332 | — | IC50 | > | 1000.0 | nM | - |