Assay Detail
Binding
CHEMBL4020428
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Inhibition of recombinant human AKR1B1 using pyridine-3-aldehyde as substrate
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL1900) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.59 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4089816 | — | — | 1 | 7.82 |
| CHEMBL3318218 | — | — | 1 | 7.01 |
| CHEMBL4071421 | — | — | 1 | 6.75 |
| CHEMBL4062779 | — | — | 1 | 6.70 |
| CHEMBL4081954 | — | — | 1 | 6.69 |
| CHEMBL4098452 | — | — | 1 | 6.66 |
| CHEMBL4089817 | — | — | 1 | 6.56 |
| CHEMBL4068704 | — | — | 1 | 6.50 |
| CHEMBL4071420 | — | — | 1 | 6.50 |
| CHEMBL4060049 | — | — | 1 | 6.47 |
| CHEMBL4084456 | — | — | 1 | 6.41 |
| CHEMBL4081953 | — | — | 1 | 5.02 |
| CHEMBL4092206 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4089816 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3318218 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4071421 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4062779 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4081954 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL4098452 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4089817 | — | IC50 | = | 277.0 | nM | 6.56 |
| CHEMBL4068704 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4071420 | — | IC50 | = | 314.0 | nM | 6.50 |
| CHEMBL4060049 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4084456 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4081953 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4092206 | — | IC50 | > | 10000.0 | nM | - |