Assay Detail
Binding
CHEMBL4020982
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Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Lys(Ac)-pNA as substrate after 30 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.55 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080164 | — | — | 1 | 8.31 |
| CHEMBL4090847 | — | — | 1 | 8.14 |
| CHEMBL4069853 | — | — | 1 | 8.07 |
| CHEMBL4065026 | — | — | 1 | 7.84 |
| CHEMBL4083054 | — | — | 1 | 7.52 |
| CHEMBL4086475 | — | — | 1 | 7.28 |
| CHEMBL4066741 | — | — | 1 | 7.22 |
| CHEMBL4061184 | — | — | 1 | 7.12 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.09 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.88 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
| CHEMBL4091752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080164 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4090847 | — | IC50 | = | 7.17 | nM | 8.14 |
| CHEMBL4069853 | — | IC50 | = | 8.56 | nM | 8.07 |
| CHEMBL4065026 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL4083054 | — | IC50 | = | 30.45 | nM | 7.52 |
| CHEMBL4086475 | — | IC50 | = | 52.17 | nM | 7.28 |
| CHEMBL4066741 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4061184 | — | IC50 | = | 76.13 | nM | 7.12 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 131.26 | nM | 6.88 |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 1000.0 | nM | - |
| CHEMBL4091752 | — | IC50 | > | 1000.0 | nM | - |