Assay Detail
Binding
CHEMBL4020987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length HDAC1 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.07 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080164 | — | — | 1 | 8.97 |
| CHEMBL4069853 | — | — | 1 | 8.89 |
| CHEMBL4065026 | — | — | 1 | 8.87 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.70 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 7.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080164 | — | IC50 | = | 1.06 | nM | 8.97 |
| CHEMBL4069853 | — | IC50 | = | 1.28 | nM | 8.89 |
| CHEMBL4065026 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 110.0 | nM | 6.96 |