Assay Detail
Binding
CHEMBL4020989
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Inhibition of recombinant human full length HDAC6 using Fluor-de-Lys as substrate after 60 mins by spectrofluorimetric analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.81 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065026 | — | — | 1 | 8.17 |
| CHEMBL4069853 | — | — | 1 | 8.08 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 8.01 |
| CHEMBL4080164 | — | — | 1 | 7.84 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.96 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065026 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4069853 | — | IC50 | = | 8.32 | nM | 8.08 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 9.85 | nM | 8.01 |
| CHEMBL4080164 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL27759 | ENTINOSTAT | IC50 | > | 10000.0 | nM | - |