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Assay Detail

CHEMBL4021142

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human NALM6 cells assessed as reduction in cell viability up to 200 uM after 48 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NALM-6
Confidence 1 — Organism
Curated By Autocuration

Target

NALM-6 (CHEMBL614187)
Type CELL-LINE
Organism Homo sapiens

Publication

Trifluoromethyl arylamides with antileukemia effect and intracellular inhibitory activity over serine/arginine-rich protein kinases (SRPKs).
Siqueira RP, Barros MVA, Barbosa ÉAA, Onofre TS, Gonçalves VHS, Pereira HS, Silva Júnior A, de Oliveira LL, Almeida MR, Fietto JLR, Teixeira RR, Bressan GC.
Eur J Med Chem (2017) 134 : 97 -109
PubMed 28407594 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.42 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4088175 1 5.22
CHEMBL4063664 1 4.77
CHEMBL4090561 1 4.45
CHEMBL4070140 1 4.29
CHEMBL4082741 1 4.28
CHEMBL4099751 1 4.23
CHEMBL4072259 1 4.20
CHEMBL4061480 1 4.20
CHEMBL4064277 1 4.15
CHEMBL4091101 1 -
CHEMBL1735559 1 -
CHEMBL4095905 1 -
CHEMBL4068588 1 -
CHEMBL4071534 1 -
CHEMBL4097828 1 -
CHEMBL4072870 1 -
CHEMBL1311317 1 -
CHEMBL4103160 1 -
CHEMBL1482272 1 -
CHEMBL4078881 1 -
CHEMBL4073315 1 -
CHEMBL2131797 1 -
CHEMBL1490444 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4088175 IC50 = 6000.0 nM 5.22
CHEMBL4063664 IC50 = 17000.0 nM 4.77
CHEMBL4090561 IC50 = 35700.0 nM 4.45
CHEMBL4070140 IC50 = 51900.0 nM 4.29
CHEMBL4082741 IC50 = 52300.0 nM 4.28
CHEMBL4099751 IC50 = 59000.0 nM 4.23
CHEMBL4072259 IC50 = 63200.0 nM 4.20
CHEMBL4061480 IC50 = 63600.0 nM 4.20
CHEMBL4064277 IC50 = 70600.0 nM 4.15
CHEMBL4091101 IC50 - -
CHEMBL1735559 IC50 - -
CHEMBL4095905 IC50 - -
CHEMBL4068588 IC50 - -
CHEMBL4071534 IC50 - -
CHEMBL4097828 IC50 - -
CHEMBL4072870 IC50 - -
CHEMBL1311317 IC50 - -
CHEMBL4103160 IC50 - -
CHEMBL1482272 IC50 - -
CHEMBL4078881 IC50 - -
CHEMBL4073315 IC50 - -
CHEMBL2131797 IC50 - -
CHEMBL1490444 IC50 - -