Assay Detail
ADMET
CHEMBL4021257
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR-2 (unknown origin) by HTRF method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.10 | 10.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 10.07 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.32 |
| CHEMBL4104302 | — | — | 1 | 7.26 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 0.086 | nM | 10.07 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL4104302 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 180.0 | nM | 6.75 |