Assay Detail
Functional
CHEMBL4021371
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Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of largazole zinc-binding group analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173445 | LARGAZOLE | — | 1 | 8.80 |
| CHEMBL4078721 | — | — | 1 | 6.32 |
| CHEMBL4099942 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173445 | LARGAZOLE | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL4078721 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4099942 | — | IC50 | = | 497.0 | nM | 6.30 |